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Thus, rats subjected to ADF for a prolonged period of time (i.e., 6 months, equivalent to approximately 14 years in humans) developed reduced left ventricular diastolic compliance, a 3-fold increase in interstitial myocardial fibrosis and diminished cardiac reserve ( 3 Putative behavioral and biological processes that may link intermittent fasting to cardiovascular disease We suggest that increased loss of lean mass, circadian misalignment of food consumption and/or compromised food quality may underpin the adverse effects of IF on cardiovascular health in genetically predisposed individuals (Figure 1)